Nā hiʻohiʻona o ka polypeptide

ʻO nā lāʻau lapaʻau polypeptide e pili ana i nā polypeptides me nā hopena therapeutic kikoʻī ma o ka synthesis chemical, recombination gene a me ka unuhi ʻana o nā holoholona a me nā mea kanu, i hoʻokaʻawale ʻia i nā polypeptides endogenous (e like me enkephalin a me thymosin) a me nā polypeptides exogenous (e like me ka snake venom a me ka waikawa sialic).ʻO ke kaumaha molecular pili o nā lāʻau polypeptide aia ma waena o nā lāʻau lapaʻau protein a me nā lāʻau micromolecule, nona nā pono o nā lāʻau micromolecule a me nā lāʻau protein.Ke hoʻohālikelike ʻia me nā lāʻau lapaʻau micromolecule, loaʻa nā lāʻau polypeptide i ka hana biological kiʻekiʻe a me ka kikoʻī ikaika.Ke hoʻohālikelike ʻia me nā lāʻau lapaʻau, ʻoi aku ka maikaʻi o nā lāʻau polypeptide, haʻahaʻa immunogenicity, maʻemaʻe kiʻekiʻe a me nā kumu kūʻai haʻahaʻa.

Hiki ke hoʻopili pololei ʻia ka polypeptide e ke kino, a wikiwiki ka wikiwiki o ka absorption, a ʻo ka absorption o ka polypeptide ka mea nui.Eia kekahi, ʻaʻole hiki i nā peptides ke lawe wale i nā meaʻai, akā hoʻouna pū i ka ʻike kelepona e kauoha i nā aʻalolo.Loaʻa i nā lāʻau lapaʻau Polypeptide nā hiʻohiʻona o ka hana kiʻekiʻe, ke koho kiʻekiʻe, ka haʻahaʻa haʻahaʻa a me ka pili kiʻekiʻe o ka pahuhopu, akā i ka manawa like, loaʻa iā lākou nā hemahema o ka hapalua o ke ola pōkole, ka ʻilihune cell membrane permeability a me ke ala hoʻokahi o ka hoʻokele.

I ka ʻike ʻana i nā hemahema o nā lāʻau lapaʻau polypeptide, ua hana ka poʻe noiʻi i nā hoʻāʻo ʻole ma ke ala o ka optimizing peptides e hoʻomaikaʻi i ka bioavailability o nā lāʻau polypeptide.ʻO ka cyclization o nā peptides kekahi o nā ala e hoʻonui ai i nā peptides, a ʻo ka hoʻomohala ʻana o nā peptides cyclic i lawe mai i ka wanaʻao i nā lāʻau lapaʻau polypeptide.Pono nā peptides cyclic i ka lāʻau lapaʻau ma muli o ko lākou kūpaʻa metabolic maikaʻi loa, ke koho a me ka pili, ka permeability membrane cell a me ka loaʻa waha.Loaʻa i nā peptides cyclic nā hana olaola e like me ka anti-cancer, anti-infection, anti-fungus a me anti-virus, a he mau molekala lāʻau hoʻohiki loa.I kēia mau makahiki i hala iho nei, ua ʻike nui ʻia nā lāʻau lapaʻau cyclic peptide, a ua hahai nā hui lāʻau lapaʻau i ke ʻano o ka hoʻomohala ʻana i ka lāʻau lapaʻau hou a hoʻonohonoho i nā ala lāʻau cyclic peptide i kēlā me kēia.

Ua hoʻolauna ʻo Kauka Chen Shiyu mai Shanghai Institute of Pharmacology, Chinese Academy of Sciences i nā lāʻau peptide cyclic i ʻae ʻia mai 2001 a 2021 i loko o kāna mau lāʻau peptide cyclic i ʻae ʻia i nā lāʻau lapaʻau hope ʻelua.I nā makahiki he 20 i hala iho nei, aia he 18 mau ʻano o nā lāʻau cyclic peptide ma ka mākeke, ma waena o ka nui o nā peptides cyclic e hana ana i ka synthesis o ka pā hale a me nā pahuhopu β-1,3-glucanase ka nui loa, me 3 mau ʻano kēlā me kēia.ʻO nā lāʻau lapaʻau cyclic peptide i ʻae ʻia e uhi i ka anti-infection, endocrine, digestive system, metabolism, tumor/immunity a me ka ʻōnaehana nūnū waena, ma waena o nā lāʻau anti-infection a me endocrine cyclic peptide lāʻau no 66.7%.Ma ke ʻano o nā ʻano cyclization, nui nā lāʻau cyclic peptide cyclic i hoʻopaʻa ʻia e nā paʻa disulfide a cyclized e nā paʻa amide, a ua ʻae ʻia nā lāʻau 7 a me 6.